| Molecular Formula | C30H44N2O14S2 |
| Molar Mass | 720.80536 |
| Melting Point | 189-191° |
| Appearance | Color Crystals |
| Physical and Chemical Properties | Chemical properties crystal. Melting point 189-191 ℃. |
| Use | Use cholinergic drugs. |
| Toxicity | LD50 in mice: 15 g/kg orally, 826 mg/kg s.c. (Miura); in dogs: >10 g/kg orally (Takai) |
| Raw Materials | Isopropyl acetate Choline hydroxide |
Pharmacodynamics
Ethylcholine naphthalene disulfonate is a choline-like drug that directly acts on smooth muscle choline receptors. It can excite gastrointestinal smooth muscle to produce contraction, promote gastrointestinal emptying, and promote bile discharge from the gallbladder and common bile duct. However, it has no effect on the secretion of gastric juice, the acidity of gastric juice and the concentration of pepsin.
clinical application
chronic gastritis, biliary dyskinesia, digestive dysfunction after digestive tract surgery such as nausea, vomiting, loss of appetite and abdominal distension.
Production method
Suspend bis (choline)-naphthalene-1, 5 disulfonate in acetonitrile, add lactic anhydride diacetate, and heat the mixture to reflux for 3 hours. The resulting product is cooled to precipitate crystallization. Filtered products.
category
Toxic substances
Toxicity classification
low toxicity
Acute toxicity
oral-rat LDL0: 15000 mg/kg; Oral-mouse LD50:15000 mg/kg
flammability hazard characteristics
Combustible; heat decomposition releases toxic nitrogen oxides and sulfur oxide smoke
storage and transportation features
Warehouse ventilation low temperature drying
Fire extinguishing agent
Dry powder, foam, sand, water